Why was the CAPiTA trial done?

Published by Anaya Cole on

Why was the CAPiTA trial done?

Pfizer conducted the CAPiTA study (Community-Acquired Pneumonia Immunization Trial in Adults) as part of its regulatory commitments to global regulatory authorities.

What was the randomization ratio in the CAPiTA trial?

Investigational Products. Participants were randomly assigned in a 1:1 ratio to receive PCV13 or placebo by intramuscular injection in the right deltoid.

Why was the community acquired pneumonia immunization trial in adults study performed?

Background. The Community Acquired Pneumonia immunization Trial in Adults (CAPiTA) was conducted to evaluate 13-valent pneumococcal conjugate vaccine (PCV13) for the prevention of vaccine-type community-acquired pneumonia (VT-CAP) and vaccine-type invasive pneumococcal disease (VT-IPD) in adults aged ⩾65 years.

When will Prevnar 20 be available?

On June 8, 2021, Pfizer announced the U.S. Food and Drug Administration (FDA) approved PREVNAR 20 for the prevention of invasive disease and pneumonia in adults age 18 years or older.

Do you need Prevnar 20 if you had Prevnar 13 and Pneumovax 23?

Before the FDA approval of Prevnar 20, the Centers for Disease Control and Prevention (CDC) recommended the use of two other pneumococcal vaccines — Prevnar 13 (PCV13) and Pneumovax 23 (PPSV23).

How long does Prevnar 20 last?

Younger than 2 years old: four shots (at 2 months, 4 months, 6 months, and then a booster between 12 and 15 months) 65 years old or older: two shots, which will last you the rest of your life. Between 2 and 64 years old: between one and three shots if you have certain immune system disorders or if you’re a smoker.

How often should you get a pneumonia shot if you are over 65?

If you get pneumococcal vaccines for the first time at 65 or older, you will need two shots, one year apart. If you’ve had only one pneumococcal vaccine in your lifetime, you may now need an additional shot. If you had the pneumococcal vaccine before you were 65, you may now need one or two additional shots.

How long does the shingles shot last?

Protection from shingles vaccine lasts about 5 years. While the vaccine was most effective in people 60 through 69 years old, it also provides some protection for people 70 years old and older.

How many shingles shots do you need after 65?

If you’re 50 or older, get Shingrix Your risk of shingles and complications increases as you age. You need 2 doses of Shingrix. Get the second dose 2 to 6 months after you get the first dose.

Is there a downside to the shingles vaccine?

Most people got a sore arm with mild or moderate pain after getting Shingrix, and some also had redness and swelling where they got the shot. Some people felt tired, had muscle pain, a headache, shivering, fever, stomach pain, or nausea.

What does capita stand for?

Exploratory efficacy endpoints in the Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA). Vaccine. 2017 Mar 1;35 (9):1266-1272. doi: 10.1016/j.vaccine.2017.01.032.

Was the trial completed according to the protocol?

The trial was completed in accordance with the protocol. All data were analyzed according to the vaccine administered. All participants who underwent randomization were vaccinated by investigators who were unaware of the study-vaccine assignments.

Where did the Julius clinical trial take place?

The trial was conducted by Julius Clinical, a spin-off of the Julius Center for Health Sciences and Primary Care, a division of the University Medical Center Utrecht in the Netherlands. Fifty-eight sentinel hospitals were used for the surveillance of CAP and IPD.