Which cancer is associated with hypertrophic osteoarthropathy?

Published by Anaya Cole on

Which cancer is associated with hypertrophic osteoarthropathy?

Hypertrophic pulmonary osteoarthropathy (HPO) is a rare paraneoplastic syndrome that is frequently associated with lung cancer; however, the incidence of clinically apparent HPO is not well known.

Is clubbing the same as hypertrophic osteoarthropathy?

Hypertrophic osteoarthropathy (HOA), consists of the presence of digital clubbing, increased periosteal activity of the tubular bones, arthralgias, and joint effusion and is characterized by abnormal proliferation of the skin, soft tissues, and osseous tissues in the distal parts of extremities.

Is hypertrophic osteoarthropathy Painful?

Hypertrophic pulmonary osteoarthropathy is a paraneoplastic syndrome seen in patients with lung cancer. This condition is characterized by the presence of digital clubbing, periosteal thickening, synovial thickening, and severe pain of the affected joints.

What is primary hypertrophic osteoarthropathy?

Primary hypertrophic osteoarthropathy (PHO) is a genetically and clinically heterogeneous inherited disorder characterized by digital clubbing and osteoarthropathy, with variable features of pachydermia, delayed closure of the fontanels, and congenital heart disease.

What does digital clubbing indicate?

Clubbed fingers is a symptom of disease, often of the heart or lungs which cause chronically low blood levels of oxygen. Diseases which cause malabsorption, such as cystic fibrosis or celiac disease can also cause clubbing. Clubbing may result from chronic low blood-oxygen levels.

Is digital clubbing painful?

Clubbing – skin surrounding nails may be red and tender. Thickening of the skin. Thickening of tubular bones. Periostosis (this is the abnormal deposition of bone around the outside of a bone), that may be symptomless or may cause severe burning and deep-seated pain of the extremities.

What is the Schamroth window test?

The Schamroth window test can be used to identify or confirm clubbing. If 2 opposing fingers are held back to back against each other, a diamond-shaped space should normally appear between the nail beds and the nails of the 2 fingers. In clubbing, this space (or window) is missing.

What is the pathophysiology behind digital clubbing?

Digital clubbing has classically been associated with chronic infections such as bronchiectasis, lung abscess, empyema, pulmonary tuberculosis, and infective endocarditis. Both inflammatory bowel disease (Crohn disease more than ulcerative colitis) and chronic liver disease have been associated with clubbing.

What is hypertrophic osteoarthropathy (Hoa)?

Hypertrophic osteoarthropathy (HOA) is a medical condition characterized by abnormal proliferation of skin and periosteal tissues involving the extremities and characterized by three clinical features: digital clubbing (also termed Hippocratic fingers), periostosis of tubular bones, and synovial effusions.

What is the clinical presentation of hypertrophic osteoarthropathy?

Hypertrophic osteoarthropathy has a variable clinical presentation, ranging from asymptomatic morphologic and radiographic findings to pain accompanying the changes of the fingers and toes 5.

What are the treatment options for Primary hypertrophic osteoarthropathy?

In primary hypertrophic osteoarthropathy (or in cases where the underlying condition could not be treated), symptomatic relief can be obtained by use of NSAIDs, corticosteroids or bisphosphonates 6,7. General imaging differential considerations include: Consider the differential for a smooth periosteal reaction.

Which radiographic findings are characteristic of hyperosmolar osteoarthritis (Hoa)?

Joint involvement in HOA is characterized radiographically by the presence of synovial effusion without evidence of joint space narrowing, erosions, or periarticular osteopenia.