What protein does PINK1 code for?

Published by Anaya Cole on

What protein does PINK1 code for?

The PINK1 gene provides instructions for making a protein called PTEN induced putative kinase 1. This protein is found in cells throughout the body, with highest levels in the heart, muscles, and testes.

What happens during mitophagy?

Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIX and its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins.

Does PINK1 play a role in PTEN-induced systemic growth inhibition?

Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila Cell Rep. 2021 Mar 23;34(12):108875.doi: 10.1016/j.celrep.2021.108875.

Does PINK1 play a role in mitochondrial homeostasis?

Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila The maintenance of mitochondrial homeostasis requires PTEN-induced kinase 1 (PINK1)-dependent mitophagy, and mutations in PINK1 are associated with Parkinson’s disease (PD).

Does PTEN-induced kinase 1-dependent mitophagy play a role in Parkinson’s disease?

The maintenance of mitochondrial homeostasis requires PTEN-induced kinase 1 (PINK1)-dependent mitophagy, and mutations in PINK1 are associated with Parkinson’s disease (PD). PINK1 is also downregulated in tumor cells with PTEN mutations. However, there is limited information concerning the role of P …

Can Pin1 inhibitors be used as anti-cancer drugs?

Accordingly, Pin1 inhibitors as anti-cancer drugs have been developed. Interestingly, recent intensive studies have demonstrated Pin1 to be responsible for the onset or development of nonalcoholic steatosis, obesity, atherosclerosis, lung fibrosis, heart failure and so on, all of which have been experimentally induced in Pin1 deficient mice.