What is the function of interleukin 11?
What is the function of interleukin 11?
It Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion.
What is the interleukin gene?
The IL1A gene provides instructions for making a protein called interleukin-1 alpha. Interleukins are a group of proteins that are made primarily in immune system cells. They are involved in cell-to-cell communication and have a wide variety of functions within the immune system.
What interleukins cause inflammation?
Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase proteins.
Where is the IL-11 gene located?
The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. IL-11 is a member of the IL-6 -type cytokine family, distinguished based on their use of the common co-receptor gp130.
What does IL-11 stand for?
It is also known under the names adipogenesis inhibitory factor ( AGIF) and was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin . The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein.
What animals are homologous to the IL11 gene?
Homologs of the IL11 gene: The IL11 gene is conserved in chimpanzee, dog, mouse, and rat. The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
Is there a link between IL-11 and cancer?
More recently it has been discovered that over expression of IL-11 is associated with a variety of cancers and may provide a link between inflammation and cancer.