What is penicillinase-producing Staphylococcus?

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What is penicillinase-producing Staphylococcus?

An antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections. A penicillin used to treat penicillinase-producing bacterial infections that are susceptible to the drug.

What is penicillinase-producing bacteria?

methicillin. In methicillin. …to a bacterial enzyme called penicillinase (beta-lactamase). This enzyme is produced by most strains of Staphylococcus and disrupts certain types of penicillins by hydrolyzing the beta-lactam ring that is central to the antimicrobial activity of these drugs.

What is the meaning of penicillinase?

Medical Definition of penicillinase : beta-lactamase specifically : a beta-lactamase that hydrolyzes and inactivates penicillin.

How is penicillinase produced?

A bacterial strain exposed to penicillin may produce an extracellular enzyme called penicillinase which leaves the bacterial cell and degrades the penicillin around it by hydrolysing the cyclic amide bond in the beta-lactam ring of penicillin and thus inactivates the antibiotic.

Does S. aureus produce penicillinase?

Kirby first demonstrated that penicillin was inactivated by penicillin-resistant strains of S. aureus (14). Bondi and Dietz (15) subsequently identified the specific role of penicillinase. More than 90% of staphylococcal isolates now produce penicillinase, regardless of the clinical setting.

What is an example of penicillinase?

Background. Three major penicillinase-resistant penicillins are available in the United States: dicloxacillin (dye klox” a sil’ in), oxacillin (ox” a sil’ in) and nafcillin (naf sil’ in).

What is the mode of action of penicillinase?

Penicillinase-resistant penicillins work by inhibiting bacterial cell wall synthesis (cell walls are necessary to protect the bacteria from their environment and keep the contents of the cell together) by attacking the peptidoglycans (the mesh-like structure that increases the strength of the cell wall), leading to the …

Is penicillinase a beta-lactamase?

Penicillinase-type of beta-lactamase responsible for the ampicillin resistance in Escherichia coli NTUH 9501-1.

What is the importance of penicillinase?

Penicillinase-resistant penicillins are useful for treating infections caused by β-lactamase–producing staphylococci. Therapeutic applications for penicillinase-resistant penicillins include treatment or prevention of infections in the upper or lower respiratory tract, skin, bones, and joints.

Why is penicillinase useful?

What are penicillinase-resistant penicillins?

Chemically, the penicillinase -resistant penicillins contain side groups that protect the drugs from being inactivated by bacterial β-lactamases. Methicillin, oxacillin, and nafcillin are usually given parenterally; dicloxacillin is given orally.

Which germ could produce an enzyme that destroys the penicillin molecule?

During these years, the bacterium acquired a plasmid containing a gene for the enzyme penicillinase, which destroys the penicillin molecule. This germ could produce an enzyme, penicillinase, that destroyed the penicillin molecule.

What is beta a penicillinase?

A purified enzyme preparation obtained from cultures of a strain of Bacillus cereus; formerly used to treat slowly developing or delayed penicillin reactions. n. Any of several beta-lactamase enzymes that cleave the beta-lactam ring in penicillins. Penicillinases are found in many penicillin-resistant bacteria.

Where are penicillinases found?

Penicillinases are found in many penicillin-resistant bacteria. The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

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