What is osteosarcoma?
What is osteosarcoma?
Osteosarcoma is a type of bone cancer that begins in the cells that form bones. Osteosarcoma is most often found in the long bones — more often the legs, but sometimes the arms — but it can start in any bone. In very rare instances, it occurs in soft tissue outside the bone.
What is the treatment for metastatic osteosarcoma?
Metastatic osteosarcoma: a challenging multidisciplinary treatment Osteosarcoma is the most common malignant bone tumor, currently treated with pre-and postoperative chemotherapy in association with the surgical removal of the tumor. About 15-20% of patients have evidence of metastases at diagnosis, mostly in the lungs.
What is the prevalence of metastatic osteosarcoma at diagnosis?
About 15-20% of patients have evidence of metastases at diagnosis, mostly in the lungs. Patients with metastatic disease still have a … Osteosarcoma is the most common malignant bone tumor, currently treated with pre-and postoperative chemotherapy in association with the surgical removal of the tumor.
What is the who histologic classification of bone cancer?
World Health Organization (WHO) histologic classification of bone tumours divides osteosarcomas into central and surface tumours, and recognises a number of subtypes within each group . This paper refers only to the conventional central high grade primary osteosarcoma of bone, which represents about 90% of all cases of osteosarcoma.
Can osteosarcoma develop in the lumbar spine?
Most osteosarcoma tumors develop in the bones around the knee and upper arm, but this disease can develop in any bone—including the bones of your spine. The above illustrates a section of the lumbar (low back) spine; specifically L3-L4.
What other disorders can be differentiated from osteosarcoma?
Related Disorders. The main disorders that need to be differentiated from osteosarcoma are others forms of cancer or tumors that affect the bone. These include chondrosarcoma, malignant fibrous histiocytoma, Ewing sarcoma, fibrosarcoma, chordoma, malignant giant cell tumor of bone, and lymphoma that affects bone.
How common is osteosarcoma in children?
Osteosarcoma is a type of bone cancer that usually develops in the osteoblast cells that form bone. It happens most often in children, adolescents, and young adults. Approximately 800 new cases of osteosarcoma are reported each year in the U.S. Of these cases, about 400 are in children and teens.
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What are the types of high-grade osteosarcomas?
Other high-grade osteosarcomas include: Extraskeletal: a tumor that starts in a part of the body other than a bone (but still makes bone tissue) These uncommon tumors fall between high-grade and low-grade osteosarcomas.
What do we know about extraskeletal osteosarcomas in Denmark?
A follow-up investigation of 25 cases of extraskeletal osteosarcomas diagnosed at the Center for Bone and Soft Tissue Tumors, Aarhus University Hospital, Denmark, in the period from 1970-1995 was undertaken. The immunohistochemical profile of these tumors was evaluated using a panel of 10 antibodies …
Can osteosarcoma start in the arm?
Osteosarcoma is most often found in the long bones — more often the legs, but sometimes the arms — but it can start in any bone. Osteosarcoma tends to occur in teenagers and young adults, but it can also occur in younger children and older adults. Treatment usually involves chemotherapy and surgery.
What is the prognosis of osteosarcoma?
Treatment for osteosarcoma has greatly improved over the years. The outlook (prognosis) and treatment decisions depend on where the osteosarcoma starts, tumor size, the type and grade of osteosarcoma, and whether the cancer has spread. After completion of treatment, people need lifelong monitoring for potential late effects of intense chemotherapy.
What are Skip metastases in osteosarcoma?
High-grade osteosarcomas may occasionally present with skip metastases, which are non-contiguous smaller tumor foci in the same bone or in adjacent bone 11. The WHO classification of bone tumors lists the histologic types of osteosarcoma, which can be further organized by the state of underlying bone and site of origin within the bone:
What are the histologic subtypes of osteosarcomas?
Conventional osteosarcomas can be further divided by histological subtype: Osteosarcomas are bulky tumors where a heterogeneous cut surface demonstrates areas of hemorrhage, fibrosis, and cystic degeneration. Their extension within the medullary cavity is often much more extensive than the bulky part of the tumor would suggest.
What are the demographics of osteosarcoma?
Osteosarcomas can be either primary or secondary, and these have differing demographics: primary osteosarcoma: typically occurs in young patients (10-20 years) with 75% taking place before the age of 20 because the growth centers of the bone are more active during puberty/adolescence 3; slight male predominance