What is cisplatin and pemetrexed?
What is cisplatin and pemetrexed?
Pemetrexed and cisplatin is a combination of two chemotherapy drugs. Pemetrexed is also called Alimta. You might have it as a treatment for non small cell lung cancer (NSCLC) or mesothelioma (cancer of the outer covering of the lungs). Find out more about these types of cancers from our A to Z list.
Is cisplatin a strong chemo drug?
Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical . In ovarian germ cell cancer, the use of cisplatin brings about high response rates .
How long can you take gemcitabine and cisplatin?
You usually have GC chemotherapy as cycles of treatment. Each cycle takes 3 weeks. You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.
Can cisplatin pemetrexed shrink Tumours?
Cisplatin + pemetrexed (cis/pem) is given to shrink lung tumors and decrease symptoms of lung cancer. Cisplatin + pemetrexed can be given either after surgery to eliminate microscopic cells, or cisplatin + pemetrexed can be given before surgery to shrink the size of the tumor and minimize the size of the lung surgery.
What kind of chemo is pemetrexed?
Pemetrexed belongs to the class of chemotherapy drugs called antimetabolites. Antimetabolites are very similar to normal substances within the cell. When the cells incorporate substances like pemetrexed into themselves during growth, the cells lose the ability to divide.
What does Alimta do?
Pemetrexed is used to treat certain types of cancer (such as lung cancer, mesothelioma). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.
What is the most common side effect of cisplatin?
Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.
Will I lose my hair with cisplatin?
Cisplatin treatment resulted in loss of hair cells and morphologic changes suggestive of hair cell damage, including misshapen, swollen or shrunken cells. These changes were highly attenuated by the addition of EGCG.
How effective is gemcitabine and cisplatin?
Cisplatin plus gemcitabine significantly improved progression-free survival, with a median of 8.0 months (95% CI, 6.6 to 8.6) in the cisplatin–gemcitabine group as compared with 5.0 months (95% CI, 4.0 to 5.9) in the gemcitabine-only group (P<0.001).
Is Alimta chemo or immunotherapy?
Alimta (pemetrexed) for Injection is a chemotherapy drug indicated for treatment of patients with locally advanced or metastatic non-squamous non-small cell lung cancer.
How successful is pemetrexed?
Median overall survival was 10.5 months for both treatment groups. The 1-year survival rate was 49.9% for pemetrexed/oxaliplatin patients and 43.9% for pemetrexed/carboplatin.
When is cisplatin used?
Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.
How will I feel after cisplatin?
This medicine often causes nausea and vomiting. However, it is very important that you continue to receive this medicine even if you begin to feel ill. Other medicines may be given to you to help with the nausea and vomiting. Ask your doctor for other ways to lessen these effects.
How long can you take cisplatin?
Your course of chemotherapy Each cycle of cisplatin usually takes 21 days (3 weeks). You usually have the cisplatin on the first day of each cycle. But this will depend on the type of cancer you have. Your doctor or nurse will discuss your treatment plan with you.
Why do you give B12 and folic acid with Alimta?
SAN FRANCISCO—Adding vitamin B12 and folic acid to chemotherapy with pemetrexed disodium (Alimta) reduces the incidence of severe life-threatening toxicities, according to research presented at the 37th Annual Meeting of the American Society of Clinical Oncology (ASCO abstract 300).
How often is Alimta given?
The recommended dose of ALIMTA is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. Skin rash has been reported more frequently in patients not pretreated with a corticosteroid.
Is pemetrexed well tolerated?
Pemetrexed is a key anticancer agent for treatment of advanced non-small cell lung cancer (NSCLC). Pemetrexed is generally well tolerated, but individual-patient differences exist in severity of adverse events.
What are long term side effects of cisplatin?
Cisplatin (CDDP) is a frequently employed chemotherapeutic drug both in curative and palliative settings. When cancer patients are cured due to CDDP therapy, they unfortunately often experience severe long‐term side effects including irreversible hearing loss (ototoxicity) and permanent neuronal and renal damage.