Is raloxifene water soluble?

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Is raloxifene water soluble?

As raloxifene HCl is practically insoluble in water, an inclusion complex of the antiosteoporotic raloxifene HCl (RLX) in hydroxypropyl-β-cyclodextrin (HPβCD) was prepared and characterized.

What is raloxifene HCl used for?

Raloxifene is used to help prevent and treat thinning of the bones (osteoporosis) only in postmenopausal women. It works like an estrogen to stop the bone loss that can develop in women after menopause, but it does not increase the bone density as much as daily 0.625 mg doses of conjugated estrogens.

What is raloxifene HCl 60mg?

Raloxifene is used by women to prevent and treat bone loss (osteoporosis) after menopause. It slows down bone loss and helps to keep bones strong, making them less likely to break. Raloxifene may also lower the chance of getting a certain type of breast cancer (invasive breast cancer) after menopause.

What is another name for raloxifene?

Raloxifene, sold under the brand name Evista among others, is a medication used to prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids.

Can you crush raloxifene?

Do not break or crush the tablet before taking it. A broken or crushed tablet may taste bad and there is a possibility that you will receive an incorrect dose. Your doctor will tell you how long you should continue to take Evista.

What is the black box warning for raloxifene?

WARNING: Raloxifene may rarely cause serious blood clots, especially in the legs or lungs. Women who have or had blood clots (including in the legs, lungs, or eyes) should not take raloxifene.

Can raloxifene be crushed?

Is raloxifene a prodrug?

As a result, higher doses must be administered to obtain an efficacy equivalent to that achieved with TAM. To improve oral bioavailability and antitumor potential, RAL diphosphate was prepared as a prodrug.

Which medications Cannot be crushed?

Drugs that should not be crushed are those that are:

  • Designed to be controlled release.
  • Coated for protection or taste.
  • Dissolvable.
  • Liquid-filled gel capsules.
  • Hazardous or irritants.
  • Intended for a small therapeutic window.

Can modified release tablets be crushed?

The majority of extended-release products should not be crushed or chewed, although there are some newer slow-release tablet formulations available that are scored and can be divided or halved (e.g., Toprol XL).

Why are tablets film coated?

Due to the increase in tablet size caused by sugar coating, drug manufacturers have largely changed to using ‘film coatings’. These are very thin layers of a safe ingredient placed around the tablet to again protect the tongue from the flavour of the contents and protect the contents from moisture and light.

How do you dissolve pills in water?

Studies show you can dissolve some medications in water without changing their effectiveness. For example, you can crush a levothyroxine (Synthroid) tablet and place it in 1 to 2 teaspoons of water before drinking it.

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