Is allopurinol used for tumor lysis syndrome?
Is allopurinol used for tumor lysis syndrome?
It is usually given orally at 600 mg daily for prophylaxis and 600-900 mg daily (up to a maximum of 500 mg/m2 daily) for treatment of tumor lysis syndrome. Patients unable to take oral medications can be given IV allopurinol.
How does allopurinol work?
Allopurinol works by reducing the amount of uric acid made by body cells. In gout, this helps prevent uric acid crystals building up in the joints. This helps prevent joints becoming swollen and painful. In cancer, some cancer treatments kill cancer cells and uric acid is then released from these cells.
Which enzyme is inhibited by allopurinol?
Allopurinol, a purine analog, is a structural isomer of hypoxanthine and inhibits xanthine oxidase enzyme.
When should allopurinol be used?
Allopurinol is used to prevent or lower high uric acid levels in the blood. It is also used to prevent or lower excess uric acid levels caused by cancer medicines or in patients with kidney stones. A high uric acid level can cause gout or gouty arthritis (joint pain and inflammation).
Does allopurinol thin blood?
Allopurinol may also increase the effect of warfarin and other drugs that thin the blood. These are known as anticoagulants. If you’re taking blood thinners, you may need your clotting time tested more frequently to check you’re still on the right dose.
What is the action of allopurinol?
Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. High levels of uric acid may cause gout attacks or kidney stones. Allopurinol is used to prevent gout attacks, not to treat them once they occur.
How to prevent and manage tumor lysis syndrome?
– Uric acid >8 mg/dL (475.8 micromole/L) or 25% increase; – Potassium >6 mEq/L (6 mmol/L) or 25% increase; – Phosphorus >6.5 mg/dL (2.1 mmol/L) for children or >4.5 mg/dl (1.45 mmol/L) for adults or 25% increase; and – Calcium >7 mg/dL (1.75 mmol/L) or 25% increase.
How do we treat tumor lysis syndrome?
a short,thin tube ( cannula ) that the nurse puts into a vein in your arm or hand
What is the treatment for tumor lysis syndrome?
Vigorous Hydration and Monitoring Urine Output. The person with TLS will receive ample fluids through one or more intravenous (IV) lines with a goal of maintaining a urine output that
Which agents may cause tumor lysis syndrome (TLS)?
Tumor lysis syndrome most commonly occurs during cytotoxic chemotherapy, although biological agents such as anti‐CD20 monoclonal antibodies have also been shown to induce TLS , .