How is mucous membrane pemphigoid diagnosed?

Published by Anaya Cole on

How is mucous membrane pemphigoid diagnosed?

Mucous membrane pemphigoid is the designation given to a heterogeneous group of rare chronic autoimmune disorders that tend to cause waxing and waning bullous lesions of the mucous membranes, often with subsequent scarring and morbidity. Diagnosis is by skin biopsy and direct immunofluorescence.

What causes ocular cicatricial pemphigoid?

The cause of ocular cicatricial pemphigoid (OCP) is unknown. Genetic factors and several triggers can increase the likelihood of the onset of OCP. Individuals with HLA-DR2, HLA-DR4 (HLA-DR*0401), and HLA-DQw7 (DQB1*0301) are more susceptible to OCP.

How do you test for pemphigoid?


  1. A skin biopsy. In this test, a piece of tissue from a blister is removed and examined under a microscope.
  2. Blood tests. One purpose of these tests is to detect and identify antibodies in your blood that are known to be present with pemphigus.
  3. An endoscopy.

What autoimmune disease causes thick mucus?

Cystic fibrosis, a disease that causes thick, sticky mucus to build up in the lungs. Autoimmune disorders, such as rheumatoid arthritis or Sjögren syndrome.

How is ocular cicatricial pemphigoid diagnosed?

Therefore, the clinical diagnosis of cicatricial pemphigoid is made when there is progression of a symblepharon without a history of local radiation or severe perennial allergic conjunctivitis. Diagnosis can be confirmed by conjunctival biopsy showing linear antibody deposition on the basement membrane.

What does direct immunofluorescence test for?

Direct immunofluorescence (DIF) test for tissue-bound autoantibodies provides a useful adjunct for the diagnosis of autoimmune bullous disorders, helping to classify histologically similar conditions which differ in their treatment protocols and prognosis.

Is pemphigoid an autoimmune disease?

Pemphigus is an autoimmune disorder. Normally, your immune system produces antibodies to fight off harmful invaders, such viruses and bacteria. But in pemphigus, the body produces antibodies that damage cells of your skin and mucous membranes.

What is OCP test for eyes?

Disease Entity. Ocular Cicatricial Pemphigoid is abbreviated OCP. OCP is considered a subtype of Mucous Membrane Pemphigoid (abbreviated MMP), and these terms are sometimes used interchangeably. OCP is a type of autoimmune conjunctivitis that leads to cicatrization (i.e. scarring) of the conjunctiva.

What is cicatricial scarring?

Scarring, or cicatricial alopecia, is an inflammatory condition that destroys hair follicles, causing scarring and permanent hair loss. The Mount Sinai’s Alopecia Center of Excellence can help. Dermatologists have deep experience diagnosing and treating this form of alopecia.

Is cicatricial alopecia reversible?

Secondary cicatricial alopecia is also irreversible, though destruction of the hair follicle is incidental to a non-follicle-directed cause, such as thermal burns, metastatic cancer, trauma or radiation.

How is cicatricial pemphigoid treated?

Individuals with widespread or severe MMP may be treated with systemic corticosteroids such as prednisone and/or immunosuppressive drugs such as mycophenolate mofetil, cyclophosphamide or azathioprine.

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