How does hyperlipidemia cause hyponatremia?

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How does hyperlipidemia cause hyponatremia?

In states of hyperproteinemia or hyperlipidemia, there is an increased mass of the nonaqueous components of serum and a concomitant decrease in the proportion of serum composed of water. Thus, pseudohyponatremia results because the flame photometry method measures sodium concentration in whole plasma.

What causes low sodium and seizures?

Chronic, severe vomiting or diarrhea and other causes of dehydration. This causes your body to lose electrolytes, such as sodium, and also increases ADH levels. Drinking too much water. Drinking excessive amounts of water can cause low sodium by overwhelming the kidneys’ ability to excrete water.

Does hypertriglyceridemia cause hyponatremia?

In classic hyperlipidemia (hypertriglyceridemia)-induced hyponatremia, several equations have been published to correct errors in serum potassium, chloride, and sodium measurements.

Why does hyperglycemia cause hyponatremia?

Hyperglycemia causes hyperosmolality, and the water moves from intracellular space to extracellular space, which in turn produces a dilutional decrease in serum sodium level. Therefore, hyperglycemic patients are mostly mildly hyponatremic.

How does hyperglycemia affect sodium levels?

The effect of hyperglycemia is well known for its lowering of serum sodium levels. The most commonly used correction factor is a 1.6 mEq per L (1.6 mmol per L) decrease in serum sodium for every 100 mg per dL (5.6 mmol per L) increase in glucose concentration.

Is low sodium linked to seizures?

Low blood sodium is common in older adults, especially those who are hospitalized or living in long-term care facilities. Signs and symptoms of hyponatremia can include altered personality, lethargy and confusion. Severe hyponatremia can cause seizures, coma and even death.

Can hypokalemia cause seizures?

Unlike other electrolyte alterations, hypokalemia or hyperkalemia rarely causes symptoms in the CNS, and seizures do not occur (8).

Why is there hyponatremia in diabetic ketoacidosis?

Diabetic ketoacidosis (DKA) causes a hyperosmolar state driven by the osmotic force of hyperglycemia in the intravascular space. Dilutional hyponatremia is common due to water driven into the intravascular space from inside cells. On rare occasions, hypernatremia is found in DKA.

What is pseudohyponatremia?

Pseudohyponatremia is a lab error that by itself does not carry an increased risk of morbidity or mortality; however, many conditions that result in pseudohyponatremia correlate with increased health risk. In many cases, direct measurement of serum sodium level with direct potentiometry is not necessary.

How does hypocalcemia cause seizures?

Importantly, hypocalcemia can cause seizures without concomitant tetany because low ionized Ca concentrations in the cerebrospinal fluid are associated with increased excitability in the central nervous system [2, 3].

How can dehydration cause seizures?

Seizures can result from severe imbalances in electrolytes due to dehydration. Dehydration can reduce the amount of blood in the body, which can put strain on the heart and cause shock. Shock is a dangerous decrease in blood pressure, which can be fatal.

Do low sodium levels cause seizures?

Does hypernatremia cause seizures?

Hypernatremia is defined as a serum sodium concentration in plasma >145 mEq/L. Whereas hyponatremia may cause seizures, hypernatremia is more likely to be a result of seizure activity (e.g., generalized tonic–clonic seizures). Intracellular glycogen is metabolized to lactate in muscle during seizures.

Can hypernatremia cause seizures?

In patients with hypernatremia the rupture of cerebral veins, as well as the intracerebral and subarachnoid hemorrhages, which are induced by brain shrinkage, can in turn provoke seizures.

How does high glucose affect sodium?

The osmotic effect of hyperglycemia moves extravascular water to the intravascular space. For each 100 mg/dL of glucose over 100 mg/dL, the serum sodium level is lowered by approximately 1.6 mEq/L. When glucose levels fall, the serum sodium level rises by a corresponding amount.

Can pseudohyponatremia cause seizure?

Severe and rapidly evolving hyponatremia may cause seizures, which are usually generalized tonic-clonic, and generally occur if the plasma sodium concentration rapidly decreases to <115 mEq/L.

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